Signal Library / Half-Life Guide
Signal Library · Reference Tool
Peptide Half-Life Guide
Approximate elimination half-lives for Signal Library compounds with meaningful published or well-estimated pharmacokinetic data.
Research use only. Half-life values below are approximate and compiled from published pharmacokinetic literature where available, for research-planning context only. Compounds without meaningful independently published or reasonably estimable human PK data are intentionally left off this guide rather than guessed at — see each compound’s Signal Library entry for what research does exist. This is not medical advice or a dosing recommendation. Always verify against primary literature and your Certificate of Analysis.
26 Compounds Listed
5 Categories
26 Shown Now
~3 min Fastest Documented
~4 hours
Estimated, rodent PK studies
Injectable
~2–3 days
Estimated
Injectable
~2 hours
Clinical PK data on thymalfasin
Injectable
~30 minutes
Estimated
Injectable
~1 hour
Estimated, limited human PK data
Injectable
~20–30 minutes
Estimated, limited clinical PK data
Injectable
~1 hour
Estimated
Injectable
20–30 hours
Injectable (SubQ/IM)
CJC-1295 (DAC): 6–8 days
Ipamorelin: ~2 hours
Injectable
~7 minutes
Active fragment, plasma
Intranasal
~3 minutes
Active fragment, plasma
Intranasal
~minutes (IV)
Precursor forms (NMN, NR) studied separately
Injectable (IV/SubQ)
~5–6.5 hours
Published low-dose clinical PK
Oral / Injectable
~10–15 minutes
Plasma, IV
Injectable
~28 minutes
Published clinical PK
Injectable
~5–6 hours
Estimated from published early-phase PK
Injectable
~26 minutes
Published clinical PK
Injectable
~30 minutes
Published Phase II PK
Injectable
~24–36 hours
Biphasic clearance
Injectable
~5–7 days
Estimated, weekly-dosing profile in published trials
Injectable
~1 hour
Estimated, limited published human PK
Injectable
~3 hours
Estimated
Injectable
~30–60 minutes
Plasma
Topical / Injectable
MT-II: ~30–40 min
MT-I: formulation-dependent (implants extend duration)
Injectable
Compound
Category
Route
Approximate Half-Life
BPC-157 Healing & Recovery
Injectable
~4 hours Estimated, rodent PK studies
TB-500 Healing & Recovery
Injectable
~2–3 days Estimated
Thymosin Alpha-1 Healing & Recovery
Injectable
~2 hours Clinical PK data on thymalfasin
DSIP Healing & Recovery
Injectable
~30 minutes Estimated
LL-37 Healing & Recovery
Injectable
~1 hour Estimated, limited human PK data
ARA-290 Healing & Recovery
Injectable
~20–30 minutes Estimated, limited clinical PK data
KPV Healing & Recovery
Injectable
~1 hour Estimated
IGF-LR3 Healing & Recovery
Injectable (SubQ/IM)
20–30 hours
CJC-1295 / Ipamorelin Longevity & Cognitive
Injectable
CJC-1295 (DAC): 6–8 days Ipamorelin: ~2 hours
Semax Longevity & Cognitive
Intranasal
~7 minutes Active fragment, plasma
Selank Longevity & Cognitive
Intranasal
~3 minutes Active fragment, plasma
MK-677 Longevity & Cognitive
Oral
~24 hours
NAD+ Longevity & Cognitive
Injectable (IV/SubQ)
~minutes (IV) Precursor forms (NMN, NR) studied separately
Methylene Blue Longevity & Cognitive
Oral / Injectable
~5–6.5 hours Published low-dose clinical PK
Ipamorelin Longevity & Cognitive
Injectable
~2 hours
Glutathione Longevity & Cognitive
Injectable
~10–15 minutes Plasma, IV
Kisspeptin Longevity & Cognitive
Injectable
~28 minutes Published clinical PK
SS-31 Longevity & Cognitive
Injectable
~5–6 hours Estimated from published early-phase PK
Tesamorelin Weight & Metabolic
Injectable
~26 minutes Published clinical PK
AOD-9604 Weight & Metabolic
Injectable
~30 minutes Published Phase II PK
HCG Weight & Metabolic
Injectable
~24–36 hours Biphasic clearance
Mazdutide Weight & Metabolic
Injectable
~5–7 days Estimated, weekly-dosing profile in published trials
MOTS-c Weight & Metabolic
Injectable
~1 hour Estimated, limited published human PK
Epitalon Bioregulators
Injectable
~3 hours Estimated
GHK-Cu Aesthetics & Skin
Topical / Injectable
~30–60 minutes Plasma
Melanotan I/II Aesthetics & Skin
Injectable
MT-II: ~30–40 min Published Phase 1 PK · MT-I: formulation-dependent
No compounds match that search or filter.
Half-life describes how fast a compound clears the bloodstream — it isn’t the same as how long its effects last, or how long it stays viable in storage. For handling and storage windows, see the Shelf-Life Guide , and for the general lab technique behind reconstitution, see Reconstitution Basics .
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