ARA-290
An erythropoietin-derived peptide studied for tissue-protective signaling independent of red-blood-cell production.
Overview
ARA-290 is a small peptide derived from the tertiary structure of erythropoietin (EPO), the hormone best known for stimulating red blood cell production. ARA-290 was engineered to retain EPO’s tissue-protective signaling activity while eliminating the blood-doping-relevant erythropoietic (red-cell-boosting) effects, making it a distinct research focus from EPO itself.
Mechanism of Action
ARA-290 is studied as a selective agonist of the innate repair receptor (IRR), a complex distinct from the classical EPO receptor that mediates red blood cell production. Activation of the IRR has been studied for anti-inflammatory and cytoprotective signaling in nerve and vascular tissue, without the hematologic effects associated with EPO.
Cited Research
Innate repair receptor pharmacology
Characterized ARA-290’s selective activity at the IRR, distinct from the classical EPO receptor.
Neuropathic pain research
Studied in small nerve fiber and neuropathic pain research contexts.
Anti-inflammatory signaling
Examined for cytoprotective effects on endothelial and nerve tissue under inflammatory stress.
This is a summary, not an exhaustive review. Search the primary literature yourself: ARA-290 on PubMed →
Safety & Handling
ARA-290 should be handled only by qualified personnel in a laboratory setting, stored and reconstituted per its Certificate of Analysis, and kept refrigerated once reconstituted. It is not evaluated or approved by the FDA for any human or veterinary use.
Frequently Asked Questions
Does ARA-290 affect red blood cell counts like EPO?
No — it was specifically engineered to avoid the classical EPO receptor responsible for red blood cell production, while retaining EPO’s separate tissue-protective signaling activity.
Is ARA-290 legal to purchase?
It’s legal to sell and purchase as a research chemical for laboratory use in the U.S. It is not approved by the FDA as a drug or supplement for human consumption.
How should it be stored?
Keep the lyophilized powder refrigerated or frozen prior to reconstitution. Once reconstituted, keep refrigerated and use within the timeframe on its Certificate of Analysis.
Is this page medical advice?
No. This page summarizes published literature for research and educational context only. It does not recommend a dose, protocol, or use in humans or animals outside a laboratory setting.
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