SLU-PP-332
A synthetic ERR agonist studied as an “exercise mimetic” for its effects on mitochondrial and metabolic gene expression.
Overview
SLU-PP-332 is a small-molecule compound developed by researchers at Saint Louis University, designed to activate the estrogen-related receptors (ERRs) — a family of nuclear receptors involved in mitochondrial biogenesis and energy metabolism. It’s a newer research compound that has generated interest as a potential “exercise mimetic,” a compound that reproduces some metabolic effects of exercise pharmacologically.
Mechanism of Action
SLU-PP-332 activates ERRα, ERRβ, and ERRγ, nuclear receptors that regulate genes involved in mitochondrial biogenesis, oxidative metabolism, and muscle-fiber-type composition. This is the same receptor family activated naturally during endurance exercise, which is the basis for the “exercise mimetic” research framing. It’s sometimes studied alongside BAM15, a mitochondrial uncoupler with a complementary metabolic mechanism.
Cited Research
ERR receptor pharmacology
Foundational characterization of SLU-PP-332 as a pan-ERR agonist.
Exercise-mimetic research
Studied in rodent models for effects on endurance capacity and mitochondrial gene expression without physical training.
Metabolic disease models
Explored for effects on markers relevant to obesity and metabolic dysfunction in animal studies.
This is a summary, not an exhaustive review. Search the primary literature yourself: SLU-PP-332 on PubMed →
Safety & Handling
SLU-PP-332 should be handled only by qualified personnel in a laboratory setting, stored per its Certificate of Analysis, and kept in a cool, dry place away from light. It is not evaluated or approved by the FDA for any human or veterinary use.
Frequently Asked Questions
What is BAM15, and how does it relate to SLU-PP-332?
BAM15 is a mitochondrial uncoupler studied for a complementary metabolic mechanism, and the two are sometimes researched together as a combination — available as our SLU-PP/BAM 15 blend product.
Is SLU-PP-332 legal to purchase?
It’s legal to sell and purchase as a research chemical for laboratory use in the U.S. It is not approved by the FDA as a drug or supplement for human consumption.
How should it be stored?
Store in a cool, dry place away from direct light and moisture, as indicated on the Certificate of Analysis.
Is this page medical advice?
No. This page summarizes published literature for research and educational context only. It does not recommend a dose, protocol, or use in humans or animals outside a laboratory setting.
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