5-Amino-1MQ
A small-molecule NNMT inhibitor studied for its role in cellular energy metabolism and adipocyte signaling.
Overview
5-Amino-1MQ is a small-molecule research compound (not a peptide) studied as a selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), which has drawn research interest in metabolic and adipose-tissue biology over the past decade.
Mechanism of Action
NNMT is an enzyme that regulates cellular NAD+ and SAM (S-adenosylmethionine) levels, and is notably elevated in adipose (fat) tissue. By inhibiting NNMT, 5-Amino-1MQ has been studied in animal models for its effects on adipocyte energy metabolism, with research interest centered on whether NNMT inhibition can influence fat-cell metabolic activity.
Cited Research
NNMT enzyme biology
Characterized NNMT’s role and elevated expression in fat-tissue metabolism.
NAD+/SAM metabolism studies
Examined how NNMT inhibition affects cellular NAD+ and SAM cofactor levels.
Rodent metabolic research
Studied body-composition and metabolic-rate effects of NNMT inhibition in mouse models.
Cellular senescence research
A newer research area examining NNMT inhibition’s relationship to cellular aging markers.
This is a summary, not an exhaustive review. Search the primary literature yourself: 5-Amino-1MQ on PubMed →
Safety & Handling
5-Amino-1MQ should be handled only by qualified personnel in a laboratory setting, stored per its Certificate of Analysis, and kept in a cool, dry place away from light. It is not evaluated or approved by the FDA for any human or veterinary use.
Frequently Asked Questions
Is 5-Amino-1MQ a peptide?
No — it’s a small molecule, not a peptide chain. It’s grouped with metabolic-research compounds because of its studied role in adipose-tissue enzyme biology.
Is 5-Amino-1MQ legal to purchase?
It’s legal to sell and purchase as a research chemical for laboratory use in the U.S. It is not approved by the FDA as a drug or supplement for human consumption.
How should it be stored?
Store in a cool, dry place away from direct light and moisture, as indicated on the Certificate of Analysis.
Is this page medical advice?
No. This page summarizes published literature for research and educational context only. It does not recommend a dose, protocol, or use in humans or animals outside a laboratory setting.
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