AOD-9604
A modified fragment of human growth hormone (hGH 176-191), studied for lipolytic signaling independent of the GH-receptor pathway.
Overview
AOD-9604 is a modified fragment of the C-terminal region of human growth hormone (amino acids 176-191), developed by Australian researchers in the early 2000s specifically to isolate the fat-metabolizing region of the GH molecule while minimizing effects on growth and insulin sensitivity associated with full-length GH.
Mechanism of Action
Research has focused on AOD-9604’s proposed lipolytic (fat-breakdown) signaling in adipose tissue, independent of the GH-receptor/IGF-1 pathway that mediates most of full-length growth hormone’s other effects. This was the original research rationale: isolate the “fat-burning” fragment from the rest of GH’s biological activity.
Cited Research
Original fragment-isolation research
Documents the isolation of the lipolytic region of growth hormone independent of its growth-promoting activity.
Adipose tissue signaling
Examined lipolytic signaling pathways activated in fat-cell models.
Clinical trial literature
Explored body-composition outcomes in registered clinical trials.
Comparative GH-fragment pharmacology
Compared AOD-9604’s activity profile to full-length growth hormone and other GH-axis compounds.
This is a summary, not an exhaustive review. Search the primary literature yourself: AOD-9604 on PubMed →
Safety & Handling
AOD-9604 should be handled only by qualified personnel in a laboratory setting, stored and reconstituted per its Certificate of Analysis, and kept refrigerated once reconstituted. It is not evaluated or approved by the FDA for any human or veterinary use.
Frequently Asked Questions
Is AOD-9604 legal to purchase?
It’s legal to sell and purchase as a research chemical for laboratory use in the U.S. It is not approved by the FDA as a drug or supplement for human consumption.
Is AOD-9604 the same as growth hormone?
No — it’s a small fragment of one region of the GH molecule, specifically studied to isolate lipolytic signaling from GH’s other, broader growth-promoting effects.
How should it be stored?
Keep the lyophilized powder refrigerated or frozen prior to reconstitution. Once reconstituted, keep refrigerated and use within the timeframe on its Certificate of Analysis.
Is this page medical advice?
No. This page summarizes published literature for research and educational context only. It does not recommend a dose, protocol, or use in humans or animals outside a laboratory setting.
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