Semax
A heptapeptide derived from ACTH(4-10), studied in the neuropharmacology literature for neurotrophic and cognitive-signaling pathways.
Overview
Semax is a synthetic peptide developed in Russia in the 1980s, derived from a fragment of adrenocorticotropic hormone (ACTH). Unlike ACTH itself, Semax was designed to retain research interest in neurological signaling without significant hormonal (adrenal-stimulating) activity, and has been studied extensively in the Russian neuropharmacology literature.
Mechanism of Action
Research has focused on Semax’s relationship to brain-derived neurotrophic factor (BDNF) expression and other neurotrophic signaling pathways, alongside effects on monoamine neurotransmitter systems such as dopamine and serotonin. It is most often studied as an intranasal research compound, a route thought in animal models to aid peptide delivery relevant to central nervous system research.
Cited Research
BDNF & neurotrophic signaling
Examined Semax’s effect on brain-derived neurotrophic factor expression in animal models.
Monoamine neurotransmitter research
Studied effects on dopaminergic and serotonergic signaling pathways.
Cerebral ischemia research
Animal models of reduced cerebral blood flow were a major early research application for Semax.
Cognitive-performance studies
Explored in animal learning and memory paradigms.
This is a summary, not an exhaustive review. Search the primary literature yourself: Semax on PubMed →
Safety & Handling
Semax should be handled only by qualified personnel in a laboratory setting, stored and reconstituted per its Certificate of Analysis, and kept refrigerated once reconstituted. It is not evaluated or approved by the FDA for any human or veterinary use.
Frequently Asked Questions
Is Semax legal to purchase?
It’s legal to sell and purchase as a research chemical for laboratory use in the U.S. It is not approved by the FDA as a drug or supplement for human consumption.
What’s the difference between Semax and NA Semax Amidate?
NA Semax Amidate is a modified variant with an added amidate group, which is studied for a potentially longer half-life than the original Semax structure. They are related but structurally distinct research compounds.
How should Semax be stored?
Keep refrigerated or frozen and protected from light prior to use. Follow the handling window indicated on its Certificate of Analysis once prepared for an experimental protocol.
Is this page medical advice?
No. This page summarizes published literature for research and educational context only. It does not recommend a dose, protocol, or use in humans or animals outside a laboratory setting.
Have a specific question about Semax?
Ask Signal IQ Rx — our research assistant trained on the Signal Library.