Dihexa
An angiotensin IV-derived compound studied for neurogenesis and synaptic-signaling research.
Overview
Dihexa was developed by researchers at Washington State University, derived from angiotensin IV, a peptide fragment of the renin-angiotensin system already known to have cognitive-signaling effects independent of blood-pressure regulation. Dihexa was designed to be orally bioavailable and to cross the blood-brain barrier more readily than its parent peptide.
Mechanism of Action
Research indicates Dihexa acts on the hepatocyte growth factor (HGF)/c-Met signaling system, a pathway involved in synaptogenesis — the formation of new connections between neurons. This distinguishes it mechanistically from most peptides in this library, which act on the endocrine or immune system rather than directly on neuronal growth-factor signaling.
Cited Research
HGF/c-Met pathway research
Foundational research characterizing Dihexa’s activity on hepatocyte growth factor signaling in neurons.
Synaptogenesis studies
Studied in cell-culture and animal models for effects on new synapse formation.
Angiotensin IV system research
Builds on decades of prior research into angiotensin IV’s cognitive-signaling effects, separate from its cardiovascular role.
This is a summary, not an exhaustive review. Search the primary literature yourself: Dihexa on PubMed →
Safety & Handling
Dihexa should be handled only by qualified personnel in a laboratory setting, stored per its Certificate of Analysis, and kept in a cool, dry place away from light. It is not evaluated or approved by the FDA for any human or veterinary use.
Frequently Asked Questions
Is Dihexa a peptide?
It’s technically a small-molecule analog derived from a peptide (angiotensin IV) rather than a peptide chain itself, which is part of why it’s orally stable, unlike most true peptides.
Is Dihexa legal to purchase?
It’s legal to sell and purchase as a research chemical for laboratory use in the U.S. It is not approved by the FDA as a drug or supplement for human consumption.
How should it be stored?
Store in a cool, dry place away from direct light and moisture, as indicated on the Certificate of Analysis.
Is this page medical advice?
No. This page summarizes published literature for research and educational context only. It does not recommend a dose, protocol, or use in humans or animals outside a laboratory setting.
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