Kisspeptin
A naturally occurring hormone peptide that sits at the top of the reproductive hormonal cascade.
Overview
Kisspeptin is the product of the KISS1 gene, first identified for its tumor-suppressing properties (hence its earlier name, “metastin”) before researchers discovered its central role in triggering the reproductive hormonal cascade. It sits upstream of GnRH, LH, and FSH, making it one of the master regulators of the reproductive endocrine system.
Mechanism of Action
Kisspeptin binds the KISS1 receptor (GPR54) on GnRH-producing neurons in the hypothalamus, triggering the release of gonadotropin-releasing hormone, which in turn stimulates LH and FSH release from the pituitary. This upstream position in the hypothalamic-pituitary-gonadal axis has made it a research focus for understanding puberty onset and reproductive hormone regulation more broadly.
Cited Research
GnRH neuron activation
Characterized Kisspeptin/GPR54 signaling as the primary upstream trigger for GnRH release.
Puberty-onset research
Studied for its role in triggering the onset of puberty in animal and human genetic research.
Original tumor-suppressor research
Originally identified and named “metastin” for anti-metastatic properties before its reproductive role was discovered.
This is a summary, not an exhaustive review. Search the primary literature yourself: Kisspeptin on PubMed →
Safety & Handling
Kisspeptin should be handled only by qualified personnel in a laboratory setting, stored and reconstituted per its Certificate of Analysis, and kept refrigerated once reconstituted. It is not evaluated or approved by the FDA for any human or veterinary use.
Frequently Asked Questions
Is Kisspeptin the same as GnRH?
No — Kisspeptin acts upstream of GnRH, triggering its release. They’re distinct peptides in the same reproductive-hormone signaling cascade.
Is Kisspeptin legal to purchase?
It’s legal to sell and purchase as a research chemical for laboratory use in the U.S. It is not approved by the FDA as a drug or supplement for human consumption.
How should it be stored?
Keep the lyophilized powder refrigerated or frozen prior to reconstitution. Once reconstituted, keep refrigerated and use within the timeframe on its Certificate of Analysis.
Is this page medical advice?
No. This page summarizes published literature for research and educational context only. It does not recommend a dose, protocol, or use in humans or animals outside a laboratory setting.
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