HCG

Human Chorionic Gonadotropin — an FDA-approved hormone that mimics LH, researched for testicular function, fertility, and TRT support.

Typical bottle: 5,000 IU / 10,000 IU

Research note: HCG is different from most compounds in this library because it is an FDA-approved hormone used clinically in specific medical settings, rather than an experimental research peptide. It is a prescription medication and should be used under appropriate medical supervision.

What It Is

HCG (Human Chorionic Gonadotropin) is a hormone that mimics the action of luteinizing hormone (LH) in the body. In males, LH signals the testes to produce testosterone and plays an important role in maintaining normal testicular function.

Because HCG stimulates this pathway directly, it is researched and clinically used in settings involving male fertility, testosterone production, and testicular function. It is commonly discussed alongside testosterone replacement therapy (TRT) because exogenous testosterone suppresses the body’s natural LH signaling, and HCG can help maintain testicular activity and intratesticular testosterone production during that suppression.

Who May Benefit

Male fertility research
Testosterone replacement therapy support
Testicular function during TRT
Maintaining testicular activity while on exogenous testosterone
Post-cycle hormonal recovery

What to Expect

HCG works by providing an LH-like signal to the testes rather than directly supplying testosterone. Depending on the objective, it may support testicular function, intratesticular testosterone production, testicular volume, and fertility-related parameters.

Fertility outcomes take time to change and HCG alone does not guarantee conception — sperm production depends on multiple hormonal and reproductive factors, and fertility-focused use should be guided by labs and semen analysis rather than symptoms alone.

What to Pair It With

Kisspeptin

Works upstream of HCG in the reproductive cascade, offering a complementary signaling approach.

PT-141

A separate, central-nervous-system approach to libido that’s sometimes researched alongside fertility-focused HCG protocols.

Reconstitution

5,000 IU Vial

1 mL Bac. Water (5,000 IU/mL)

10,000 IU Vial

2 mL Bac. Water (5,000 IU/mL)

Storage

Refrigerate after reconstitution, do not freeze

10 units = 500 IU20 units = 1,000 IU

Suggested Research Dosing Strategy

Fertility / Testicular Support

500–1,000 IU per administration

~3× per week (e.g. Mon/Wed/Fri) · subcutaneous.

TRT Support

500 IU

2× per week, administered concurrently with testosterone.

Post-Cycle Protocol

1,000 IU

Every other day, starting ~10 days after the final testosterone injection · 20-day protocol, 10 total administrations.

When fertility is the primary objective, treatment duration may extend for several weeks or longer depending on individual response and reproductive goals. Post-cycle protocols vary depending on the testosterone ester used and individual hormonal status.

Administration Notes

Subcutaneous administration, commonly in the abdomen.

Keep the reconstituted solution refrigerated and do not freeze it.

Fertility-focused use should ideally be guided by reproductive hormone labs and semen-analysis results rather than symptoms alone.

Research Considerations

HCG’s primary mechanism is well established clinically: it mimics LH and stimulates the testes directly. Its most important application in males is fertility preservation or restoration during testosterone therapy, since exogenous testosterone suppresses the natural LH/FSH signals needed for sperm production.

HCG does not guarantee preservation or restoration of fertility on its own, and additional therapies (such as FSH/hMG in physician-directed protocols) may be needed depending on the underlying cause.

Have a specific question about HCG? Chat with Pulse, Signal IQ’s free AI research assistant — ask about mechanisms, stacking, or how it compares to other compounds.

For research purposes only. Not approved for human use. This information is provided for educational and research purposes and is not medical advice. Signal IQ does not sell peptides.

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